NTRK Fusions Can Co-Occur With H3K27M Mutations and May Define Druggable Subclones Within Diffuse Midline Gliomas
Diffuse midline gliomas (DMGs) are incurable pediatric tumors with terribly restricted remedy choices. Many years of medical trials combining typical chemotherapies with radiation remedy have failed to enhance these outcomes, demonstrating the necessity to establish and validate druggable biologic targets inside this illness. NTRK1/2/Three fusions are present in a broad vary of pediatric cancers, together
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